Testosterone injections: Uses, safety, and side effects

Testosterone Injection: MedlinePlus Drug Information

The pituitary gland is modulated by the hypothalamus so both structures are essential for normal sex hormone production. The hypothalamus secretes a hormone called luteinizing hormone releasing hormone (LHRH) in a pulsatile manner which directs the pituitary to secrete LH. LHRH is also referred to as gonadotropin releasing hormone (GnRH). When injecting testosterone, you can choose what dosage feels right for you and your journey. Transgender men looking to maximize their potential for masculinization might opt for an average starting dose with the goal of increasing it over time to a higher dose. Non-binary, transmasculine and/or other gender variant people might feel comfortable maintaining a microdose, or a lower dose of testosterone, for more gradual changes.

Single-use packets containing 40.5mg of testosterone in alcohol-based gel OR metered-dose pump which dispenses 20.25mg of testosterone in alcohol-based gel pump. The usual starting dose is 1 packet or 4 pumps daily (about the size of 2 quarters) applied to shoulders, upper arms, and abdomen. Single-use packets containing 50mg of testosterone in 5g of alcohol-based gel OR metered-dose pump which dispenses 12.5mg of testosterone in 1.25g of alcohol-based gel per pump. The usual starting dose is 1 packet or 4 pumps daily (about the size of 2 quarters) applied to the shoulders, upper arms, and abdomen. Single-use tubes, each containing 50mg of testosterone in 5g of oil-based gel. The usual starting dose is 1 tube daily (about the size of 2 quarters) applied to the shoulders and upper arms. LUXurious Skin Members can take advantage of exclusive savings every month on some of our medical spa’s most popular treatments.

Unlike testosterone, AAS that are 17α-alkylated, like metandienone and stanozolol, are orally active. This is due to steric hindrance of C17β-position metabolism during the first-pass through the liver. In contrast, most AAS that are not 17α-alkylated, like nandrolone, are not active orally, and must instead be administered via intramuscular injection. This is almost always in ester form; for instance, in the case of nandrolone, as nandrolone decanoate or nandrolone phenylpropionate. In this post, we’ll walk you through how to safely and effectively administer your testosteroneinjections at home. It’s important to note that while it might seem a little daunting at first, with theright preparation and a few key steps, you can do it confidently and comfortably.

After the injection, the testosterone is absorbed into the bloodstream, rapidly increasing hormone levels and providing relief from symptoms of low testosterone. Depending on the prescribed dosage, TRT injections may need to be administered weekly or biweekly to maintain optimal hormone levels and achieve therapeutic benefits. TRT injections involve administering testosterone directly into the muscle tissue, typically in the gluteal region. During a TRT injection session, a healthcare provider will first clean the injection site to minimize the risk of infection. Then, using a syringe and needle, they will administer the testosterone solution into the muscle tissue. The injection process is relatively quick, typically taking only a few minutes to complete.

It’s important to follow the prescribed schedule by your healthcare provider for optimal results. On the other hand, subdermal testosterone pellets provide a consistent and prolonged release, making them an ideal choice to maintain normal testosterone levels for those seeking fewer administrations. These would be removed and relacede every few months, they are the «fire and forget» option in the TRT arsenal. For example, testosterone injections, such as testosterone shots, one of the commonly used methods, have a longer duration than other forms of testosterone replacement.

If your levels are lower than this, it’s likely you’d benefit from testosterone replacement therapy. Both enanthate and cypionate are slow-acting testosterone esters with a release time between 10 and 14 days. Some decide to inject every two weeks while others opt for weekly injections. Like other forms of TRT, testosterone injections also carry a risk of long-term side effects, including infertility, especially with long-term use. This is because TRT suppresses the hypothalamic-pituitary-gonadal (HPG) axis, thereby reducing LH and FSH production, which are key to spermatogenesis. Testosterone injections were long considered the gold standard in treating low testosterone, with its main selling points being extended dosing periods and reliable effects on the body. Oral testosterone is a prescription therapy designed to treat low testosterone levels in men.

It may take a few weeks before you start noticing differences in your body and mood once starting TRT. To allow the therapy to take full effect, healthcare providers typically wait 30 days after you start TRT to check your testosterone levels. Testosterone replacement therapy (TRT) can help improve the symptoms of low testosterone due to male hypogonadism. TRT has certain risks and benefits, so your healthcare provider will carefully evaluate if it’s safe and right for you.

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They will also do a physical exam and ask whether you have the symptoms of low T before prescribing anything. Many men report improvement in energy, sex drive, and quality of erections. Testosterone also increases bone density, muscle mass, and insulin sensitivity in some men.